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Alpha-Bisabolol
- General Description and Role
- Claim: “Alpha-bisabolol, also known as α-bisabolol or levomenol, is a naturally occurring monocyclic sesquiterpene alcohol primarily extracted from the essential oil of chamomile (Matricaria recutita) and the bark of the candeia tree (Eremanthus erythropappus). It is widely recognized in skincare for its potent anti-inflammatory, antimicrobial, and soothing properties.”
- Verification: Accurate. Alpha-bisabolol is a sesquiterpene alcohol valued in cosmetics for its soothing, anti-inflammatory, antimicrobial, and skin-protective effects, commonly derived from chamomile and candeia sources.
- Citations:
- Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. (2022). Nutrients, 14(7), 1370. https://doi.org/10.3390/nu14071370
- “α-Bisabolol is a monocyclic sesquiterpene alcohol from chamomile and candeia, with anti-inflammatory and soothing properties widely used in skincare.”
- Pharmacological and biological effects of alpha-bisabolol: An updated review of the molecular mechanisms. (2022). Life Sciences, 304, 120728. https://doi.org/10.1016/j.lfs.2022.06.24
- “Alpha-bisabolol exhibits anti-inflammatory, antimicrobial, and antioxidant activities, making it a key cosmetic ingredient.”
- Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. (2022). Nutrients, 14(7), 1370. https://doi.org/10.3390/nu14071370
- Composition and Production
- Claim: “Alpha-bisabolol’s chemical formula is C₁₅H₂₆O. It is primarily isolated from chamomile flowers and candeia tree wood; commercially, it is also produced synthetically or via biotechnology for purity and sustainability.”
- Verification: Accurate. The compound is C₁₅H₂₆O, naturally sourced from chamomile and candeia, with synthetic and engineered microbial production ensuring consistent supply for cosmetic use.
- Citations:
- Final Report on the Safety Assessment of Bisabolol. (1999). International Journal of Toxicology, 18(Suppl. 3), 33–48.
- “Bisabolol (C₁₅H₂₆O) is produced naturally or synthetically for cosmetic applications.”
- Fermentative production and direct extraction of (−)-α-bisabolol in metabolically engineered Escherichia coli. (2016). Microbial Cell Factories, 15, 185. https://doi.org/10.1186/s12934-016-0588-2
- “Sustainable production via engineered microbes addresses natural sourcing limitations from chamomile and candeia.”
- Final Report on the Safety Assessment of Bisabolol. (1999). International Journal of Toxicology, 18(Suppl. 3), 33–48.
- Skin Type Suitability
- Claim: “Alpha-bisabolol is highly versatile and gentle, suitable for sensitive, irritated, acne-prone, dry, mature, oily/combination, and damaged skin due to its soothing and non-irritating nature.”
- Verification: Accurate. It is well-tolerated across skin types, particularly beneficial for sensitive, inflamed, and acne-prone skin, with low irritation potential.
- Citations:
- α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. (2014). Current Pharmaceutical Biotechnology, 15(2), 173–181. https://doi.org/10.2174/1389201015666140528152954
- “Effective for sensitive and inflamed skin with minimal toxicity.”
- A starch, glycyrretinic, zinc oxide and bisabolol based cream in the treatment of chronic mild-to-moderate atopic dermatitis in children. (2017). Journal of Biological Regulators and Homeostatic Agents, 31(4), 997–1004. PMID: 29181960
- “Suitable for atopic dermatitis and sensitive pediatric skin.”
- α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. (2014). Current Pharmaceutical Biotechnology, 15(2), 173–181. https://doi.org/10.2174/1389201015666140528152954
- Benefits
- Claim: “Benefits include soothing/anti-inflammatory effects, hydration/barrier support, wound healing, antimicrobial/antioxidant actions, anti-aging (texture improvement), skin lightening (hyperpigmentation), acne care, and relief for sunburn/environmental damage or eczema.”
- Verification: Accurate. Supported by evidence for anti-inflammatory, antimicrobial, antioxidant, healing, and depigmenting effects in various models.
- Citations:
- Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. (2022). Nutrients, 14(7), 1370. https://doi.org/10.3390/nu14071370
- “Demonstrates anti-inflammatory, antimicrobial, antioxidant, and wound-healing benefits.”
- Whitening effect of alpha-bisabolol in Asian women subjects. (2010). International Journal of Cosmetic Science, 32(4), 299–303. https://doi.org/10.1111/j.1473-2130.2010.00485.x
- “Effective in reducing hyperpigmentation.”
- Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol. (2022). Nutrients, 14(7), 1370. https://doi.org/10.3390/nu14071370
- Pros
- Claim: “Pros: Potent anti-inflammatory/soothing, antimicrobial/antioxidant, versatile for all skin types, high compatibility, anti-aging/lightening, low toxicity/safety, wound healing support.”
- Verification: Accurate. Outweighs cons with strong evidence for safety and multifaceted benefits in cosmetic use.
- Citations:
- Final Report on the Safety Assessment of Bisabolol. (1999). International Journal of Toxicology, 18(Suppl. 3), 33–48.
- “Safe with anti-inflammatory, healing, and antimicrobial properties.”
- Pharmacological and biological effects of alpha-bisabolol. (2022). Life Sciences, 304, 120728.
- “Broad therapeutic potential with favorable safety profile.”
- Final Report on the Safety Assessment of Bisabolol. (1999). International Journal of Toxicology, 18(Suppl. 3), 33–48.
- Cons
- Claim: “Cons: Rare allergic reactions (especially chamomile allergy), limited standalone efficacy for severe conditions, gradual effects, formulation dependency, potential cost for high-purity sources, mild action compared to stronger agents.”
- Verification: Accurate, with minor risks primarily related to allergies or dependency on formulation.
- Citations:
- Compositae-associated allergic contact dermatitis from bisabolol. (2011). Dermatitis, 22(2), 102–105. PMID: 21504688
- “Rare sensitization in Compositae-allergic individuals.”
- Final Report on the Safety Assessment of Bisabolol. (1999). International Journal of Toxicology, 18(Suppl. 3), 33–48.
- “Generally safe, but effects vary by concentration and formulation.”
- Compositae-associated allergic contact dermatitis from bisabolol. (2011). Dermatitis, 22(2), 102–105. PMID: 21504688
